IN VIVO BIOCOMPATIBILITY OF HYDROXYAPATITE CONTAINING BONE CEMENT
Kemal ŞERBETÇİ1, Sibel ORHUN2, Feza KORKUSUZ3, Nesrin HASIRCI4
1Başkent Üniversitesi Biyomedikal Mühendisliği
2Sağlık Bakanlığı Ankara Acil Yardım ve Travmatoloji Hastanesi
3Orta Doğu Teknik Üniversitesi Sağlık ve Rehberlik Merkezi
4Orta Doğu Teknik Üniversitesi Kimya Bölümü
Keywords: Bone Cement, Hydroxyapatite, Bicompatibility.
Abstract
Introduction: Improving the biocompatibility of acrylic based bone cements is a current research area in orthopedic surgery and traumatology. One aspect of bone cements is improving their biomechanical properties while the other aspect is the improvement of their biocompatibility. Hyrdoxyapatite (HA) is a highly biocompatible material known to have osteoconductive properties. The aim of the study is to improve bone cements biocompatibility by adding HA. Materials and
Methods: 7% HA particles containing bone cement was prepared and its tissue reaction was compared to comercially available CMW1 bone cement. Three-month old local albino rabbits were used for in vivo testing. Both HA containing and CMW1 cements were impanted into the paravertebral muscles of the animals. Tissue reaction at muscles were assessed pathologically on day 1, 3 and 7 of implantation.
Results: 7% HA containing bone cement caused less swelling at the tissue on day one. Polimorphonuclear cells were less with HA containing bone cement on day 3 and inflammatory response was less on day 7 with this formulation.
Discussion: 7% HA containing bone cement is more biocompatible then CMW1 bone cement. This formulation can clinically be used in the near future.