Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study
Ahmet Serhat Genç1
, Ali Kerim Yılmaz2, Berna Anıl2, Esra Korkmaz Salkılıç2, Enes Akdemir2, Aykut Sancaklı3, Ahmet Mor4, Egemen Ermiş2, Lale Saka Baraz5, Nizamettin Güzel6, Lokman Kehribar6
1Department of Orthopedics and Traumatology, Samsun Traing and Research Hospital, Samsun, Türkiye
2Ondokuz Mayıs University, Faculty of Yaşar Doğu Sport Sciences, Samsun, Türkiye
3Department of Leather Engineering, Faculty of Engineering, Ege University, İzmir, Türkiye
4Department of Physical Education And Sports, Faculty of Sports Sciences, Sinop University, Sinop, Türkiye
5Department of Internal Diseases, Manisa City Hospital, Manisa, Türkiye
6Department of Orthopedics and Traumatology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
Keywords: Collagen supplement, osteoarthritis, pain, physical function, quality of life.
Abstract
Objectives: The aim of this study was to assess the effect of Naturagen® 4 Joint product, containing type 1, 2, and 3 collagen, on pain associated with osteoarthritis (OA) and to evaluate its effects on quality of life and physical functioning.
Patients and methods: This double-blind, randomized, placebo-controlled clinical study included a total of 31 patients (8 males, 23 females; mean age: 53.5±9.1 years; range, 35 to 65 years) with Grade 2-3 OA according to the Kellgren-Lawrence (KL) classification system between June 2023 and November 2023. The patients were divided into two groups: a collagen group (n=16) and a placebo group (n=15). The Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS-PS), Oxford Knee Score (OKS), Tampa Scale for Kinesiophobia (TSK), Short Form Health Survey (SF-12), Foot Function Index (FFI), Timed Up and Go (TUG), 6-Min Walking Test (6MWT), Five Repetition Sit to Stand Test (5STS), Stair Climbing Test (SCT), and Berg Balance Scale (BBS) were used. All tests were performed before and after eight weeks of collagen supplementation.
Results: Eight weeks of collagen supplementation yielded notable enhancements across all osteoarthritis-related pain and quality of life scales evaluated, including VAS, WOMAC, KOOS-PS, OKS, TSK, SF-12, and FFI scores (p<0.05). In functional evaluations, there were significant positive effects of collagen use in BBS and 6MWT results (p<0.05). In TUG, 5STS, and SCT tests, no significant difference was found between the groups (p>0.05).
Conclusion: Our study results suggest that the eight-week collagen-based supplement exerts a favorable effect on pain and quality of life levels, as well as some functional test results.
Citation: Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, Sancaklı A, et al. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study. Jt Dis Relat Surg 2025;36(1):85-96. doi: 10.52312/jdrs.2025.1965.
Study conception and design, writing: A.S.G., A.K.Y., B.A., E.K.S., E.A., A.S., A.M., E.E., L.S.B., N.G., L.K.; Data collection: A.S.G., L.S.B., N.G., L.K.; Analysis: A.K.Y., A.S., A.M., E.E.; Visualization: B.A., E.K.S., E.A. All authors read and approved the final manuscript.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.
The data that support the findings of this study are available from the corresponding author upon reasonable request.