The fluoroquinolones may positively affect tendon healing after surgical repair

Abstract

Objectives: This study aimed to evaluate the biomechanical and histological effects of fluoroquinolones on surgically repaired tendon healing.

Materials and methods: The Achilles tendons of 40 Wistar rats (mean weight: 213.5 g; range 201 to 242 g) were bilaterally surgically cut and repaired. The rats were randomly divided into four groups: the first and third groups were designated as control groups and did not receive drug therapy, whereas the second and fourth groups received 300 mg/kg ciprofloxacin for a week after the surgical procedure. The first and second groups had both tendons dissected at the end of the first week, while the third and fourth groups were dissected at the end of the third week. The left tendons were examined biomechanically, while the right tendons were examined histologically.

Results: Statistical analysis revealed that the mean maximum tensile forces of tendons in the first and second groups were 5.2±1.84 N (range, 2.9 to 8.5 N) and 11.1±2.65 N (range, 7.3 to 13.9 N), respectively, which was found to be statistically significant (p< 0.05). At the end of the third week, mean maximum tensile forces of the third and fourth groups were determined to be 20.7±5.0 N (range, 22.1 to 29.8 N) and 28.7±4.6 N (range, 22.1 to 36.8 N), respectively, which was also statistically significant (p< 0.05). Histologically, our results were compatible.

Conclusion: This study demonstrated that ciprofloxacin did not exhibit the expected adverse effects on surgically repaired tendon healing in the early stages but likely contributed to healing in the short term by affecting the inflammatory phase.

Citation: Demir T, Sener E, Öztürk AM, Bekmezci T, Esen E, Take Kaplanoglu G. The fluoroquinolones may positively affect tendon healing after surgical repair. Jt Dis Relat Surg 2024;35(3):654-661. doi: 10.52312/jdrs.2024.1832.

The study protocol was approved by the Gazi University Experimental Animals Ethics Committee (date: 28.11.2005, no: 00.00/99-17097). The study was conducted in accordance with the principles of the Declaration of Helsinki.

Conceptualization, design: T.D., E.S.; Supervision, critical review: T.D., E.S., A.M.O.; Data collection and processing: T.D., E.E., T.B., G.T.K.; Analysis: T.D., E.S., A.M.O., E.E., T.B., G.T.K.; Literature reviev: T.D., A.M.O., T.B.; Writing the article: T.D.; Materials: T.D., G.T.K., A.M.O.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

The authors received no financial support for the research and/or authorship of this article.

The data that support the findings of this study are available from the corresponding author upon reasonable request.