The role of triclosan-coated suture in preventing surgical infection: A meta-analysis

Peiliang He; Ziting Liu; Huan Chen; Guowei Huang; Wei Mao; Aiguo Li

doi:10.52312/jdrs.2023.842

Peiliang He¹, Ziting Liu², Huan Chen¹, Guowei Huang¹, Wei Mao¹, Aiguo Li¹

¹Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
²Guangzhou Red Cross Hospital, Jinan University, Operating Room, Guangzhou, China

Keywords: Hip arthroplasty, knee arthroplasty, surgical infection, triclosan-coated sutures.

Abstract

Objectives: In this meta-analysis, we aimed to compare the differences in surgical site infection (SSI) between triclosancoated and uncoated sutures after hip and knee arthroplasty.

Materials and methods: We searched PubMed, Embase, and Cochrane databases for randomized-controlled studies (RCTs) comparing triclosan-coated sutures with uncoated sutures for the prevention of SSIs after hip and knee arthroplasty. Literature screening and data curation were performed according to inclusion and exclusion criteria and the risk of bias was assessed for included research using Cochrane Handbook criteria.

Results: Three RCTs with a total of 2,689 cases were finally included, including 1,296 cases in the triclosan-coated suture group and 1,393 cases in the control group. The overall incidence of SSI was lower in the group with triclosan antimicrobial sutures (1.9%) than in the uncoated suture group (2.5%), but the difference was statistically significant (odds ratio=0.76, 95% confidence interval: [0.45-1.27], p=0.30). The differences in the results of the incidence of superficial SSI and deep SSI were not statistically significant (p>0.05).

Conclusion: The application of triclosan antimicrobial sutures did not reduce the incidence of SSI after hip and knee arthroplasty compared to the controls, and it needs further high-quality RCT studies to be improved.

Citation: He P, Liu Z, Chen H, Huang G, Mao W, Li A. The role of triclosan-coated suture in preventing surgical infection: A meta-analysis. Jt Dis Relat Surg 2023;34(1):42-49. doi: 10.52312/ jdrs.2023.842

Ethics Committee Approval

The study protocol was approved by the Guangzhou Red Cross Hospital, Jinan University Ethics Committee (date: 19.09.2022, no: 2022-222-01). The study was conducted in accordance with the principles of the Declaration of Helsinki.

Data Sharing Statement:
The data that support the findings of this study are available from the corresponding author upon reasonable request.

Author Contributions

Conception and design: H.P.; Administrative support: L.Z., C.H.; Provision of study materials or patients: H.G., M.W.; Collection and assembly of data: L.A.; Data analysis and interpretation: H.P., H.G., C.H.; Manuscript writing, final approval of manuscript: All authors.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

This study was funded by the grants from Guangzhou Municipal Science and Technology Project (No. 202002030049).