Qian Wang1, Jun-Feng Dong1,2, Xu Fang1, Yang Chen1

1Department of the Spinal Surgery, The First College of Clinical Medical Science (Yichang Central People’s Hospital), China Three Gorges University, HuBei, China
2Institute of Spinal Medicine and Trauma, China Three Gorges University, Hubei, China

Keywords: Bone cement, hardness, modification, osteogenic, vertebroplasty.


Vertebral compression fractures are more common in the elderly, particularly in postmenopausal women. Most of these people are accompanied by osteoporosis, which can easily lead to spinal deformities and fractures. Once a fracture occurs, the patient would have severe pain response, limited spinal movement, and need to stay in bed for a long time, resulting in a significant decrease in their quality of life. Percutaneous vertebroplasty (PVP) is a minimally invasive spinal surgery that injects bone cement into the diseased vertebrae for therapeutic purposes. It can quickly relieve pain and stabilize the spine. It is widely used in the treatment of vertebral compression fractures and is currently an ideal treatment method. There are many materials of bone cement used in clinical treatment, and each material has unique characteristics. Many scholars would modify the bone cement according to the advantages and disadvantages to make it more suitable for clinical use. In this review, we discuss the clinical application and modification of bone cement.

Citation: Wang Q, Dong JF, Fang X, Chen Y. Application and modification of bone cement in vertebroplasty: A literature review. Jt Dis Relat Surg 2022;33(2):467-478.

Data Sharing Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.

Author Contributions

Analysis references and wrote the manuscript: Q.W.; Conceived and designed the study. Approved the final version: J.F.D.; Search references and constructive discussions: X.F., Y.C.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The National Natural Science Foundation of China (Youth Program), No. 31600779 (to DJF); Yichang Medical and Health Research Project, No. A18-301-30 (to DJF)